Welcome to the Biomaterial R&BD Center, leading world-class non-clinical validation research.

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Core Competencies

Evaluation of Osseointegration Following Dental Implant Surface Treatment and Bone Regeneration Capacity of Dental Bone Graft Materials in Beagle Mandibles

Beagle Mandibular 1-Wall Defect Bone Graft Model

Step 1 — 1. Reflection of gingival tissue and exposure of alveolar bone

Step 2 — 2. Design of box-shaped alveolar bone defect

Step 3 — 3. Creation of box-shaped alveolar bone defect

Step 4 — 4. Refinement of box-shaped alveolar bone defect

Step 5 — 5. Confirmation of bone defect formation

Step 6 — 6. Bone graft material placement

Step 7 — 7. Bone graft material placement

Step 8 — 8. After bone graft placement

Step 9 — 9. Gingival closure (suturing)

Beagle Mandibular Immediate Implant Placement Model

Step 1 — 1. Tooth extraction

Step 2 — 2. Alveolar bone preparation

Step 3 — 3. Verification of implant placement site

Step 4 — 4. Dental implant fixture

Step 5 — 5. Immediate implant placement into extraction socket

Step 6 — 6. Implant placement

Step 7 — 7. Implant placement

Step 8 — 8. Post-implant placement

Step 9 — 9. Gingival closure (suturing)

Case Study — Animal Implantation Test for Functional Evaluation of Developed Small-Diameter Artificial Blood Vessels

Rat (small animal) abdominal aorta implantation evaluation (12 weeks) and Beagle dog (medium animal) femoral artery implantation evaluation (24 weeks).

Case study images — Implantation evaluation imagery

Histopathology Examination for Medical Device Efficacy Evaluation

H&E Stain

Skin(pig) — Skin (pig)

Retina, eye(rat) — Retina, eye (rat)

Shoulder joint(rabbit) — Shoulder joint (rabbit)

Heart(mouse) — Heart (mouse)

Calvarium, skull(rabbit) — Calvarium, skull (rabbit)

Kidney(rabbit) — Kidney (rabbit)

Liver(rat) — Liver (rat)

Special Stain

Masson's Trichrome — Masson's Trichrome stain (skin)

Safranin O — Safranin O stain (shoulder joint)

Goldner's Trichrome — Goldner's Trichrome stain (calvarium)

TUNEL stain — TUNEL stain (spleen)